Two molecular fragments surrounded by blue and amber electron clouds

Quantum chemistry. Formulation insight.

Small scale.
Big possibility.

Make the impossible bioavailable.

We look closer at molecular interactions to find clearer paths for difficult compounds.

Explore the science

A closer look. A clearer way forward.

Before the formula, there’s a molecule.

Solubility. Stability. Phase behaviour. The way molecules interact shapes the choices ahead. We connect quantum chemistry and molecular modelling with focused experiments to make those choices more informed.

Go beneath the surface.

Three connected perspectives.
One better-informed next step.

Alexander Knot

01 / Electronic structure

Chemistry starts
with electrons.

Quantum calculations help us examine how electron distribution and molecular shape influence the ways molecules can interact.

Our focus
Natural products and difficult molecules.

The question
Which formulation idea is worth testing?

The connection
Prediction, chemical insight, experimental evidence.

From insight to experiment

A smaller search.A clearer next step.

Start with a molecular question. Build a testable hypothesis. Learn from what happens at the bench.

  1. Understand the molecule.

    Explore conformers, interaction motifs and the physicochemical constraints behind its behaviour.

    ConformersInteraction motifsPhysicochemical constraints

  2. Focus the possibilities.

    Screen potential eutectic partners and composition windows to find hypotheses worth testing.

    Eutectic partnersComposition windowsTestable hypotheses

  3. Let evidence lead.

    Use focused preformulation and stability experiments to refine the model and the next decision.

    PreformulationStability experimentsModel refinement

Scientific clarity

Every prediction
needs evidence.

We keep assumptions, uncertainty and negative results visible. A result that rules out a path still moves the research forward.

A row of laboratory vials lit in blue and amber
From insightA question worth testing.
Blue-lit glass flasks on a laboratory bench
To experimentLet evidence lead.

Start a conversation

A difficult molecule.
A good place to start.

Tell us what you know, what you’ve tried, and the decision you need to make next.

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Research services · Leiden, the Netherlands